Two positions are available for postdoctoral fellows with experience in electrophysiology to study
a) regulation of Orai and TRPC channels by STIM1 and
b) regulation of fluid and bicarbonate secretion by the WNK/SPAK and IRBIT/PP1 pathways. One position is available immediately and another will become available in 6-8 months.
Present projects include determining regulation of Orai1 by a STIM1; The role of the TRPC channels and STIM1 coiled-coil domains in regulation of the channels; the physiological roles of STIM1 and the STIM1 regulator SARAF using gene deletion in mice; regulation of the Na+-HCO3- cotransporter NBCe1-B, CFTR and the SLC26 transporters by PIP2 and IRBIT; the molecular mechanism of synergism in epithelial transport. Interested postdoctoral fellows can participate in the study and of any of these topics.
The NIH is a great place to train as a postdoctoral fellow. Research at the NIH is at the highest level possible using the most sophisticated techniques, all of which are available to investigators at the NIH. The fellows will also have the opportunity to interact with many great fellows from all over the world and many renowned scientists. The NIH offers very competitive salary and excellent package of fringe benefits that include health and dental insurance.
Shmuel Muallem, Ph.D.
Chief, Epithelial Signaling and Transport Section Molecular Physiology and Therapeutics Branch NIDCR, Building 10, Room 1N-112 NIH, Bethesda MD 20892.